β-Nicotinamide Mononucleotide CAS:1094-61-7

Nicotinamide mononucleotide (NMN), o se oloa o le NAMPT tali ma se autu NAD + intermediate, faʻaleleia le faʻapalepale o le kulukose e ala i le toe faʻafoʻiina o le NAD + i le HFD-induced T2D mice.O le NMN e faʻaleleia ai foi le lagona o le inisalini hepatic ma toe faʻafoʻisia le faʻamatalaga o gene e fesoʻotaʻi ma faʻamaʻi faʻamaʻi, tali faʻamaʻi, ma le circadian rhythm, o se vaega e ala i le SIRT1 activation.O le NMN e faʻaaogaina mo le suʻesuʻeina o mafuaʻaga faʻapipiʻi i totonu o RNA aptamers ma faʻagasologa o le faʻagaioiina o ribozyme e aofia ai β-nicotinamide mononucleotide (β-NMN) -faʻagaoioi vaega RNA.

Poloaiga po'o Talosaga Fa'amatalaga

Fa'amatalaga Oloa

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Fa'aoga ma A'afiaga

β-Nicotinamide mononucleotide (NMN) o loʻo faʻaaogaina e suʻesuʻe ai mea faʻapipiʻi i totonu ole RNA aptamers ma faʻagaioiga faʻagaioiga o ribozyme e aofia ai β-nicotinamide mononucleotide (β-NMN) -faʻagaoioia RNA vaega.NMN o se nucleotide e maua mai le ribose ma le nicotinamide.Niacinamide (nicotinamide,) o se mea e maua mai i le vaitamini B3, lea e taʻua foi o le niacin.) I le avea ai o se mea faʻaola o le NAD +, atonu e aoga i le puipuia o pellagra.
β-Nicotinamide mononucleotide o se vaeluagalemu i le biosynthesis o le nicotinamide adenine dinucleotide (NAD +).Nicotinamide phosphoribosyltransferase (Nampt) faʻamalosia le condensation o le nicotinamide ma le 5-phosphoribosyl-1-pyrophosphate e gaosia ai le β-NMN, lea e mulimuli ane liua i le NAD + e le β-NMN adenyltransferase. I le 50-100 μM, β-NMN ua faʻaaogaina. NAD biosynthesis ma le glucose-stimulated insulin secretion i se Nampt +/- faʻataʻitaʻiga o isumu o faʻamaʻi metabolic, faʻaalia se matafaioi mo Nampt i le β cell function.