Tofacitinib CAS:477600-75-2 Faumea Faumea

Tofacitinib o le uluai mole mole kinase inhibitor faʻamaonia mo togafitiga o le RA.Tofacitinib o se inhibitor o vaega laiti e fa o Janus kinase (JAK): JAK1, JAK2, JAK3, ma Tyk2. Tofacitinib galue e ala i le taofiofia o le phosphorylation ma le faʻagaoioia o faʻasalalauga faʻailoga ma activators o transcription (STATs), ma taofia ai le gaosiga o mediators inflammatory. i aano sooga.

Poloaiga po'o Talosaga Fa'amatalaga

Fa'amatalaga Oloa

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Fa'aoga ma A'afiaga

Tofacitinib o se vailaʻau mo le togafitia o le gasegase oona (RA), psoriasis, faʻamaʻi faʻamaʻi, ma isi faʻamaʻi faʻamaʻi, faʻapea foʻi ma le puipuia o le teenaina o totoga.O se inhibitor o le enzyme Janus kinase 3 (JAK3), o lona uiga e faʻalavelave i le JAK-STAT ala faʻailoga e tuʻuina atu faʻamatalaga i fafo atu o le sela i totonu o le cell nucleus, e aʻafia ai le DNA transcription.Talu ai nei na faʻaalia ai i se faʻataʻitaʻiga faʻataʻitaʻiga o faʻamaʻi faʻamaʻi, tofacitinib vave faʻaleleia faʻamaʻi e ala i le faʻalavelaveina o le gaosiga o faʻasalalauga inflammatory ma le taofiofia o genes faʻalagolago i le STAT1 i totonu o le tino faʻatasi. auala, faʻapea mai e mafai e le tofacitinib ona faʻaaogaina le manuia faʻapitoa e ala i auala e le naʻo le faʻasaina o le JAK3.