(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride CAS:188416-35-5

O le (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e faʻaaogaina i le kemisi faʻafomaʻi ona o ana gaioiga faʻafomaʻi ma faʻaoga faʻafomaʻi. O lenei vailaʻau e ono faʻaalia ai uiga e teteʻe ai i le tuputupu aʻe, teteʻe i le mumū, poʻo le taofia o le enzyme e aoga i le togafitia o faʻamaʻi eseese, e aofia ai le kanesa, mumū, ma tulaga pipisi. I le sailia o vailaʻau, e faʻaaogaina e le au suʻesuʻe le (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e mamanuina ma faʻapipiʻi ai ni vailaʻau fou ma le malosi faʻaleleia, filifiliga, ma le bioavailability. E ala i le suia o lona fausaga faʻakemikolo ma le suʻesuʻeina o sootaga fausaga-gaioiga, e taumafai saienitisi e atiina ae ni vailaʻau faʻafomaʻi fou e faʻatatau i auala faʻapitoa molecular ma sini faʻapitoa o loʻo aʻafia i faʻamaʻi. E le gata i lea, o lenei vailaʻau e avea o se fausaga molecular mo le faʻapipiʻiina o sui tauva vailaʻau e ono iai faʻamatalaga faʻapitoa o le pharmacokinetic ma le faʻaleleia atili o le aoga o togafitiga. O ana fegalegaleaiga ma sini o sela, auala fa'ailoilo, ma fa'ailoga o fa'ama'i e maua ai ni malamalamaaga i ona a'afiaga fa'aletino ma faiga o gaioiga, e ta'ita'ia ai le atina'eina o togafitiga fa'apitoa ma togafitiga fa'apitoa mo gasegase e le'i fa'ataunu'uina mana'oga fa'afoma'i. E le gata i lea, o le (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e mafai ona fa'aaogaina i su'esu'ega fa'apitoa e iloilo ai lona saogalemu, aoga, ma meatotino fa'afoma'i a'o le'i fa'agasolo atu i su'ega fa'afoma'i. O lona bioactivity, aafiaga fa'afoma'i, ma a'afiaga e ono a'afia ai e iloiloina e iloa ai lona gafatia fa'amalolo ma le talafeagai mo le atina'eina atili o se oloa fa'afoma'i. I le aotelega, o le (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride o se vaila'au taua i su'esu'ega kemisi fa'afoma'i, e ofoina atu avanoa mo le mauaina o vaila'au, fa'aleleia atili o ta'ita'iga, ma le fa'afouga fa'amalolo i le sailiga e fa'afetaia'ia ai tulaga fa'afoma'i faigata ma fa'aleleia atili ai taunu'uga o gasegase.