(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid CAS:30246-33-4

O le (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, e ta'ua fo'i o le [fa'aofi le igoa tau fefa'ataua'iga po'o le igoa lautele pe a talafeagai], e taua tele i su'esu'ega fa'afoma'i ma le atina'eina o vaila'au ona o ona uiga fa'ama'i. O lenei vaila'au e avea o se poloka autu mo le fa'aputuina o vaila'au fa'ama'i e mamanuina e fa'atatau i ituaiga siama fa'apitoa ma taofia ai lo latou tuputupu a'e. O lona fa'atulagaga fa'atulagaina e mafai ai ona faia ni fegalegaleaiga sa'o ma enzymes siama, e fa'alavelaveina ai faiga taua ma o'o atu ai i aafiaga fa'ama'i. E le gata i lea, o le (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid e taua tele i le tau faasaga i siama pipisi e lamatia ai le soifua maloloina o tagata. I le tuufaatasia o lenei vailaau i totonu o vailaau faasaina, o loo taumafai ai le au suesue e atiina ae ni auala fou e togafitia ai ma faaleleia atili ai le aoga ma faaitiitia ai le tete'e. O le faiga o le vailaau e faatatau i puipui o sela o siama po o le fausiaina o porotini, e ofoina atu ai se lautele o gaioiga faasaga i siama Gram-positive ma Gram-negative, e aofia ai siama e tete'e i vailaau eseese. E le gata i lea, o taumafaiga suʻesuʻega e taulaʻi i le faʻaleleia atili o meatotino pharmacokinetic o le (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid e faʻaleleia atili ai lona bioavailability ma le tufatufaina atu i totonu o le tino. O lenei faiga faʻaleleia e aofia ai le suʻesuʻeina o auala eseese e tuʻuina atu ai vailaʻau, e pei o prodrugs, nanoparticles, poʻo liposomal formulations, e faʻaleleia atili ai le gafatia faʻamalolo o le vailaʻau ma faʻaitiitia ai aʻafiaga. I le faʻaiʻuga, o le (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid o se aseta taua i le vaega o togafitiga o faʻamaʻi pipisi, e ofoina atu ai fofo folafolaina mo le faʻafetauiina o le teteʻe atu i siama ma le faʻaleleia atili o taunuuga o maʻi. O lona faʻaaogāina tele i togafitiga faʻamaʻi pipisi e faʻamamafaina ai lona taua i vailaʻau faʻaonaponei ma faʻamamafaina ai lona gafatia e faʻaleleia atili ai le atinaʻeina o vailaʻau faʻamaʻi pipisi o le isi tupulaga.