Ansamycin CAS:72559-06-9

O Ansamycins, e pei o rifamycins, e masani ona faʻaaogaina i togafitiga faafomaʻi e togafitia ai le tele o faʻamaʻi pipisi o siama, e aofia ai le tuberculosis, lepela, ma nisi ituaiga o faʻamaʻi pipisi o le staphylococcal ma le streptococcal. O le Rifampin, o se rifamycin lauiloa, e masani ona faʻaaogaina o se vaega o togafitiga tuʻufaʻatasi mo le tuberculosis ma isi faʻamaʻi pipisi o le mycobacterial. O le faiga o le gaioiga a ansamycins e aofia ai le fusifusia i le bacterial RNA polymerase, ma taofia ai le transcription ma iu ai ina oʻo atu ai i le oti o sela o siama. O lenei faiga tulaga ese o le gaioiga e aoga ai le ansamycins e faasaga i le tele o siama Gram-positive ma Gram-negative. E mafaufau ma le faʻaeteete fomaʻi i mea e pei o le ituaiga o faʻamaʻi, talaʻaga faafomaʻi o le maʻi, ma taunuuga o suʻega o le vaivai o siama pe a faʻatonuina ansamycins. O le fua saʻo, le umi o togafitiga, ma le mataʻituina o aʻafiaga e ono aʻafia ai e taua tele mo le faʻateleina o aoga faʻafomaʻi aʻo faʻaitiitia ai lamatiaga e fesoʻotaʻi ma le faʻaaogaina o vailaʻau faʻamaʻi. O aʻafiaga leaga e fesoʻotaʻi ma ansamycins e ono aofia ai faʻalavelave i le gastrointestinal, hepatotoxicity, ma tali atu i le hypersensitivity. O le mataʻituina masani o suʻega o le galuega a le ate ma le mataʻituina lelei mo soʻo se faʻailoga o tali atu e fesoasoani e faʻamautinoa le saogalemu ma le aoga o le faʻaaogaina o ansamycins i le togafitia o faʻamaʻi pipisi o siama. I le aotelega, o ansamycins o se vasega taua o vailaʻau faʻamaʻi e eseese ona faʻaoga i le puleaina o faʻamaʻi pipisi. E ala i le faʻaaogaina talafeagai ma le mataʻituina, e mafai e le au fomaʻi ona faʻaaogaina meatotino faʻamaʻi o ansamycins e teteʻe atu ai i faʻamaʻi ma faʻaleleia atili ai taunuuga o maʻi.