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Lasmiditant CAS:439239-90-4
O le Lasmiditan, o loʻo faʻatau atu i lalo o le igoa tau fefaʻatauaʻiga o le Reyvow, o se vailaʻau fou ua mamanuina e faʻaitiitia ai osofaʻiga faʻafuaseʻi o le migraine i tagata matutua. E aofia i le vasega o selective serotonin receptor agonists, e faʻatatau tonu lava i le 5-HT1F receptor subtype. O lenei faiga o le gaioiga e ese ai le Lasmiditan mai togafitiga masani o le migraine, aua e le mafua ai le vasoconstriction, ma avea ai ma mea talafeagai mo gasegase e iai ni faʻafitauli tau cardiovascular.
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N-Methylcarbonyl-2-chloroacetamidrazone CAS:155742-64-6
O le N-Methylcarbonyl-2-chloroacetamidrazone o se vailaʻau e lauiloa i ona faʻaoga eseese i le faʻaputuga faʻaola ma le kemisi faʻamaopoopo. O lona faʻaputuga e aofia ai le faʻagasologa o le N-methylcarbamoyl chloride ma le 2-chloroacetohydrazide, ma iu ai ina maua se vailaʻau e iai ona uiga faʻatulagaina ma galuega. O lenei vailaʻau e iloga i lona gafatia e fausia ai ni mea faʻafefiloi ma ni ion uʻamea eseese, ma avea ai ma mea taua i suʻesuʻega kemisi faʻamaopoopo. E le gata i lea, o ona vaega carbonyl ma amidrazone e fesoasoani i lona tali atu ma gaioiga faʻapharmacological e ono mafai ona faia, o vaega ia o loʻo faʻaauau pea ona fiafia i ai suʻesuʻega.
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Lasmiditan HCl CAS:613677-28-4
O le Lasmiditan hydrochloride (Lasmiditan HCl) o se vailaʻau e lauiloa i lona sao i le togafitia o osofaʻiga faʻafuaseʻi o le migraine i tagata matutua. O le Lasmiditan HCl ua atiaʻe o se agonist filifilia o le serotonin receptor, e faʻatatau tonu lava i le 5-HT1F receptor subtype, o loʻo faʻatusalia ai se alualu i luma taua i le togafitiga o le migraine ona o lona faiga tulaga ese o le gaioiga ma le aoga faʻafomaʻi.
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(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone CAS:613678-03-8
O le (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone, e ta'ua fo'i o le aminopyridine methylpiperidone, o se vaila'au e iai sona a'afiaga taua i le kemisi fa'afoma'i ma su'esu'ega fa'afoma'i. O lenei vaila'au, lea na fa'aputuina e ala i le fa'agasologa o le 6-aminopicolinic acid ma le 1-methylpiperidin-4-one, o lo'o fa'aalia ai ni foliga fa'atulagaina tulaga ese e fesoasoani i lona gafatia fa'afoma'i ma le tele o galuega.
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(S)-(+)-3-Quinuclidinol CAS:34583-34-1
O le (S)-(+)-3-Quinuclidinol, e ta'ua fo'i o le quinuclidinol, o se vaila'au taua i le kemisi fa'aola ma su'esu'ega fa'afoma'i ona o lona tulaga ese i le fausaga ma lona tele o fa'aoga. O lenei vaila'au chiral e maua mai le quinuclidine ma e iai ona uiga fa'akemikolo ma fa'afoma'i tulaga ese ua tosina mai ai le mafaufau i vaega eseese o le saienisi.
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APREPITANT INTERMEDIATES CAS:171482-05-6
O vailaʻau faʻasolosolo aprepitant e iai sona sao taua i le faʻaputuga faʻafomaʻi o le aprepitant, o se vailaʻau malosi e teteʻe i le neurokinin-1 (NK1) receptor e faʻaaogaina tele i le puipuia o le niniva ma le puaʻi e mafua mai i le chemotherapy (CINV). O nei vailaʻau faʻasolosolo o ni vaega taua i le auala faʻasolosolo e tele-laʻasaga e tau atu i le faʻatulagaga mulimuli o le aprepitant. O le Aprepitant lava ia ua lauiloa mo lona aoga i le puleaina o le CINV, e ofoina atu ai le fesoasoani tele i gasegase o loʻo faia i le chemotherapy. O le faʻaputuga o le aprepitant e aofia ai ni laʻasaga autu, faʻatasi ai ma vailaʻau faʻasolosolo e avea o ni poloka faufale e mafai ai ona gaosia lelei lenei vailaʻau taua faʻafomaʻi.
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2,4,6-TRIFLUOROBENZOYL CHLORIDE CAS:79538-29-7
O le 2,4,6-Trifluorobenzoyl chloride, e ta'ua fo'i o le trifluorobenzoyl chloride, o se vaila'au taua e taua tele ona o lona fa'aogaina tele i le gaosiga fa'alenatura ma faiga fa'apisinisi. O lenei vaila'au, e ala i le fa'achlorination o le 2,4,6-trifluorobenzoic acid, e fa'aalia ai ni uiga fa'akemikolo tulaga ese e fesoasoani i lona fa'aaogaina lautele i vaega eseese.
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4-Chloro-6-iodoquinazoline CAS:98556-31-1
O le 4-Chloro-6-iodoquinazoline o se vailaʻau faʻapitoa e iai le fua faʻatatau molecular C9H5ClIN2. E faʻailoaina i le iai o atoma chlorine ma iodine e pipii i se fausaga mama quinazoline. O lenei vailaʻau e faʻaaogaina tele i suʻesuʻega faʻafomaʻi ma le faʻaputuga faʻanatura ona o ona faʻaoga talafeagai i le atinaʻeina o vailaʻau fou ma isi mole mole e faʻaaogaina i le tino.
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(R)-3-Quinuclinol CAS:25333-42-0
O le (R)-3-Quinuclinol, e ta'ua fo'i o le quinuclidinol, o se vaila'au taua i le kemisi fa'aola ma su'esu'ega fa'afoma'i ona o lona tulaga ese i le fausaga ma lona tele o fa'aoga. O lenei vaila'au chiral e maua mai le quinuclidine ma e iai ona uiga fa'akemikolo ma fa'afoma'i tulaga ese ua tosina mai ai le mafaufau i vaega eseese o le saienisi.
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![(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT235.png)
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5
O le vailaʻau (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate o se molekiu olaola lavelave e iai uiga faʻapitoa o le fausaga ma le faʻafomaʻi. E aofia i le vasega morpholine o vailaʻau, lea e masani ona faʻaaogaina i le kemisi faʻafomaʻi ona o a latou gaioiga faʻaola eseese.
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![(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0](https://cdn.globalso.com/xindaobiotech/1ZNB2ZF342ZWRNG304.png)
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0
O le (S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine o se vailaʻau e lauiloa ona o ona faʻaoga eseese i le gaosiga faʻanatura ma le kemisi faʻafomaʻi. O le gaosiga e ala i le tali atu o le (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ma le ammonia poʻo se amine, o lenei vailaʻau e iai ona foliga faʻatulagaina tulaga ese e fesoasoani i lona eseesega faʻatino ma gaioiga faʻafomaʻi e ono mafai ona faia.
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(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine CAS:608142-27-4
O le (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine o se vailaʻau e lauiloa i ona faʻaoga eseese i le gaosiga faʻanatura ma le kemisi faʻafomaʻi. O le gaosiga e ala i le tali atu o le 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone ma le ammonia poʻo se amine, o lenei vailaʻau e faʻaalia ai ni foliga faʻatulagaina tulaga ese e fesoasoani i lona fetuʻunaʻiga faʻatino ma gaioiga faʻafomaʻi e ono mafai ona faia.
