1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID CAS:113100-53-1

O le 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid e fa'aputuina e ala i metotia fa'akemikolo fa'aola, e aofia ai tali e fa'aofi ai atomu fluorine ma se vaega methyl i luga o le pyrazole core. O le molecule e maua mai ai e iai uiga fa'atulagaina tulaga ese e taua tele mo ana fa'aoga fa'amoemoeina i fa'asaienisi fa'afoma'i ma vaila'au. Fa'aoga i Fa'afoma'i O lenei fa'aputuga e fa'aalia ai le gafatia fa'afoma'i e mafua mai i ona mamanu fa'atulagaina. O Pyrazole derivatives e lauiloa mo a latou gaioiga fa'afoma'i eseese, e amata mai i mea e tete'e ai i siama i mea e tete'e ai i le tumo. O le tu'ufa'atasia o se vaega trifluoromethyl e mafai ona suia tele ai gaioiga fa'aola ma le mautu o le metabolism, e ono fa'aleleia atili ai le aoga o vaila'au ma fa'amatalaga saogalemu. Gaoioiga Fa'aola ma Faiga Fa'atino Ua fa'ailoa mai e su'esu'ega o vaila'au e suia e le trifluoromethyl e masani ona fa'aalia ai le fa'aleleia atili o le lipophilicity ma le tete'e atu i le metabolism, e a'afia ai a latou meatotino e mitiia ai, tufatufaina atu, metabolism, ma le excretion (ADME). O nei suiga e mafai ona o'o atu ai i le fa'aleleia atili o le bioavailability ma le umi o aafiaga fa'afoma'i, ma avea ai i latou ma sui tauva mo le atina'eina o vaila'au. Auala Fa'apitoa ma Atina'e O le fa'asologa o le 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid e aofia ai faiga e tele la'asaga e amata mai mea amata e maua fa'apisinisi. O le fa'aleleia atili o auala fa'apitoa e fa'amoemoe e fa'aleleia atili ai le fua, mama, ma le fa'alauteleina, e taua tele mo fa'aoga fa'apisinisi ma le gaosiga tele i nofoaga fa'afoma'i. Su'esu'ega o lo'o iai nei ma Fa'atonuga i le Lumana'i O su'esu'ega o lo'o fa'aauau pea e taula'i i le fa'amalamalamaina o le vaega atoa o gaioiga fa'aola e feso'ota'i ma le 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. E aofia ai le iloiloina o lona aoga e fa'asaga i fa'amoemoega fa'apitoa o fa'ama'i ma le fa'aleleia atili o fa'atulagaga mo fa'ata'ita'iga fa'aklinikal. O su'esu'ega i le lumana'i e ono su'esu'eina lona gafatia o se fausaga fa'avae mo le mamanuina o sui tauva fou o vaila'au ma fa'amatalaga fa'afoma'i fa'apitoa. I se aotelega, o le 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid o lo'o fa'atusalia ai se alualu i luma taua i le kemisi fa'afoma'i. O ona meatotino fa'atulagaina tulaga ese ma gaioiga fa'afoma'i e ono fa'amamafaina ai lona taua o se mataupu o su'esu'ega fa'asaienisi ma mea fou i le atina'eina o vaila'au.