(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one CAS:32384-65-9

O le fa'aputuina e ala i metotia fa'akemikolo fa'aola, o le (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one e fa'aalia ai uiga fa'atulagaina tulaga ese e taua mo ana fa'aoga eseese. O le mama tetrahydropyran, fa'atasi ai ma vaega trimethylsilyloxy, e a'afia ai ana amioga fa'akemikolo ma fegalegaleaiga fa'atasi ma isi molekiu. Fa'aoga i Faletalavai O lenei vaila'au e fa'aalia ai le folafolaga i su'esu'ega fa'akemikolo ona o ona mamanu fa'atulagaina. O Pyranone derivatives e lauiloa mo a latou gaioiga fa'akemikolo eseese, e pei o le antiviral, antifungal, ma meatotino anticancer. O le i ai o le tele o vaega trimethylsilyloxy e mafai ona fa'atonutonuina lona solubility, mautu, ma le bioavailability, e a'afia ai lona gafatia fa'amalolo. Gaoioiga Fa'aola ma Faiga O su'esu'ega e fautua mai ai e mafai e pyranone derivatives ona fegalegaleai ma faiga fa'aola ona o lo latou tutusa fa'atulagaina ma mea fa'alenatura. O vaega trimethylsilyloxy e mafai ona fesoasoani i meatotino fa'apitoa fa'akemikolo, e ono a'afia ai lona auala o gaioiga ma auala metabolic. O le malamalama i nei faiga e taua mo le fa'aleleia atili o ona aafiaga fa'amalolo. Auala Fa'apitoa ma Atina'e O le fa'asologa o le (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one e aofia ai ni faiga fa'aola lavelave e amata mai mea amata e maua i pisinisi. O le fa'aleleia atili o auala fa'apitoa e taua tele mo le ausiaina o le mama maualuga, fua, ma le fa'ateleina e mana'omia mo le gaosiga i le tele o pisinisi ma fa'aoga fa'afoma'i. Su'esu'ega o lo'o iai nei ma Fa'atonuga i le Lumana'i O lo'o fa'amoemoe su'esu'ega o lo'o fa'aauau pea e su'esu'e le tele o gaioiga fa'aola o le vaila'au, e aofia ai lona gafatia o se vaila'au e tete'e atu i siama ma lona sao i togafitiga o le kanesa. O su'esu'ega i le lumana'i atonu e taula'i i suiga fa'atulagaina e fa'aleleia atili ai lona fa'asologa fa'afoma'i ma fa'ama'i fa'apitoa. E le gata i lea, o lo'o faia su'esu'ega i lona fa'aaogaina o se vaila'au fa'apitoa eseese i le kemisi fa'aola. I le fa'ai'uga, o le (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-((trimethylsilyloxy)methyl)tetrahydro-2H-pyran-2-one o lo'o fa'atusalia ai se vaila'au taua i le kemisi fa'aola ma su'esu'ega fa'afoma'i. O ona uiga tulaga ese fa'atulagaina ma gaioiga fa'afoma'i e mafai ona avea ai ma mataupu o su'esu'ega fa'asaienisi ma fa'afouga faifai pea, ma o lo'o i ai le folafolaga mo fa'aoga eseese i vaila'au ma le saienisi o meafaitino. O le malamalama i lona fa'asologa, fegalegaleaiga fa'aola, ma le gafatia fa'amalolo e taua tele mo le fa'aogaina o ona aoga i vaega eseese.